Kidney Cancer

Studies in the area of kidney cancer reported from K. Margolin and co-researchers

Published in Gene Therapy Weekly, December 6th, 2007

According to recent research from the United States, "Purpose Oblimersen is an 18-base oligodeoxynucleotide encoding antisense to the gene for bcl-2, an anti-apoptotic protein that is upregulated in renal and other cancers. This study was designed to evaluate the combination of oblimersen with alpha-Interferon in advanced renal cancer."

"Trial endpoints were antitumor efficacy and toxicity, pharmacokinetics, and evidence of apoptosis in peripheral blood mononuclear cells. Methods Patients with measurable advanced renal cancer and 0-1 prior therapy were eligible. Treatment consisted of oblimersen, 7 mg/kg/day, as a continuous intravenous infusion 7 days of every 14 day...

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Source: Gene Therapy Weekly (2007-12-06)

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