Drug Resistance
Data on drug resistance described by M. Candelaria et al
Published in Gene Therapy Weekly, December 6th, 2007
Fresh data on drug resistance are presented in the report 'A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors.' According to recent research from Mexico, "Epigenetic aberrations lead to chemotherapy resistance; hence, their reversal by inhibitors of DNA methylation and histone deacetylases may overcome it Phase II, single-arm study of hydralazine and magnesium valproate added to the same schedule of chemotherapy on which patients were progressing. Schedules comprised cisplatin, carboplatin, paclitaxel, vinorelbine, gemcitabine, pemetrexed, topotecan, doxorubicin, cyclophosphamide, and...
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Source: Gene Therapy Weekly (2007-12-06)
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