Gene Therapy

Studies from D. Das et al in the area of gene therapy described

Published in Gene Therapy Weekly, December 6th, 2007

According to recent research published in the journal Nucleic Acids Research, "Correlation of motif occurrences with gene expression intensity is an effective strategy for elucidating transcriptional cis-regulatory logic. Here we demonstrate that this approach can also identify cis-regulatory elements for alternative pre-mRNA splicing."

"Using data from a human exon microarray, we identified 56 cassette exons that exhibited higher transcript-normalized expression in muscle than in other normal adult tissues. Intron sequences flanking these exons were then analyzed to identify candidate regulatory motifs for muscle-specific alternative splicing. Correlation of...

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Source: Gene Therapy Weekly (2007-12-06)

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