Molecular Therapies

New molecular therapies study findings reported from University of Algarve

Published in Gene Therapy Weekly, December 6th, 2007

"VLPs (virus-like particles) are promising delivery vectors for molecular therapy, since they combine the major advantages of viral vectors with significantly fewer viral vector disadvantages. The present paper describes the molecular construction of chimaeric VLPs based on minimal SIV (simian immunodeficiency virus) and HIVI components," investigators in Faro, Portugal report.

"A chimaeric protein was constructed byfusion of SIV matrix protein (p17) and HIVI p6 protein, and we demonstrated that the chimaeric proteins assemble as 80 nm nanciparticles containing similar to 7700 chimaeric protein units. Chimaeric VLPs are released from HEK-293T cells (human embryonic...

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Source: Gene Therapy Weekly (2007-12-06)

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