Cancer Gene Therapy
New findings from S.O. Freytag and co-authors describe advances in cancer gene therapy
Published in Gene Therapy Weekly, December 6th, 2007
"In preparation for a Phase I trial, we evaluated the efficacy and toxicity of replication-competent adenovirusmediated suicide gene therapy in combination with radiation in a preclinical model of pancreatic cancer. Human MiaPaCa-2 and PANC-1 pancreatic adenocarcinoma cells were found to be sensitive to the oncolytic effects of the Ad5-yCD/mutTK(SR39) rep-ADP adenovirus and also to the cytotoxic effects of the yeast cytosine deaminase ( yCD) and herpes simplex virus thymidine kinase ( HSV- 1 TKSR39) genes in vitro," scientists writing in the journal Molecular Therapy report.
"Combining Ad5yCD/ mutTK(SR39) rep-ADP-mediated suicide gene therapy with radiation...
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Source: Gene Therapy Weekly (2007-12-06)
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