Gene Therapy

Findings in gene therapy reported from A. Kunitz and co-researchers

Published in Gene Therapy Weekly, December 6th, 2007

A new study, 'DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas,' is now available. According to a study from Berlin, Germany, "Allelic losses on 19q are found in the majority of oligodendroglial tumors and approximately one-third of diffuse astrocytomas. However, the tumor suppressor genes (TSG) on 19q are still elusive."

"Using cDNA microarray expression profiling, EMP3 at 19q13.3 was among those genes showing the most pronounced expression differences. In line with this, other authors reported EMP3 as being epigenetically silenced in neuroblastomas and astrocytomas. To further investigate EMP3 as a TSG candidate on 19q13.3, we...

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Source: Gene Therapy Weekly (2007-12-06)

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