Breast Cancer

Study results from University of California broaden understanding of breast cancer

Published in Gene Therapy Weekly, December 13th, 2007

"HER2, is a member of the ErbB family of receptor tyrosine kinases, that plays a key role in the pathogenesis of breast cancer, and when overexpressed, can correlate with a particularly aggressive clinical phenotype," scientists in the United States report.

"It is estimated in roughly 18 to 20% of breast cancer patients, there is amplification of the HER2 gene resulting in aberrant overexpression of p185HER2 protein. As such, HER2 represents an attractive therapeutic target," wrote S.K. Pal and colleagues, University of California.

The researchers concluded: "In this review, we explore the clinical evolution of trastuzumab, a humanized monoclonal...

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Source: Gene Therapy Weekly (2007-12-13)

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