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Gaucher Disease

Research from E.H. Davies et al broadens understanding of Gaucher disease

Published in Gene Therapy Weekly, December 13th, 2007

"Type III Gaucher disease is one of the three recognized subtypes of Gaucher disease, an inherited deficiency of lysosomal glucocerebrosidase. Phenotypically there is a wide spectrum of visceral and neurological manifestations," researchers in London, the United Kingdom report.

"Enzyme replacement is effective in managing the visceral disease; however, the neurological manifestations remain a more challenging obstacle. There is an unfulfilled need to reliably monitor neurological disease and its response to treatment. A severity scoring tool was developed through neurological domain identification, item generation and tool formation. Domain identification was...

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