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Gene Therapy

Research on gene therapy described by K. Kondoh and colleagues

Published in Gene Therapy Weekly, December 27th, 2007

"The nuclearhormone receptor peroxisome proliferator-activated receptor (PPAR)-gamma plays a role in cancer development in addition to its role in glucose metabolism. The natural ligand of PPAR-gamma, namely, 15-deoxy-Delta(12,14) -prostaglandin J(2) (15d-PGJ(2)), has been shown to possess antineoplastic activity in cancer cells," scientists in Sapporo, Japan report.

"However, the mechanism underlying its antineoplastic activity remains to be elucidated. Inhibition of the expression of human telomerase reverse transcriptase (hTERT), a major determinant of telomerase activity, reportedly induces rapid apoptosis in cancer cells. In this study, we investigated the effect...

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