Antennas

Investigators at Fudan University have published new data on antennas

Published in Gene Therapy Weekly, December 27th, 2007

"Brain capillary endothelial cells (BCECs) have been considered as one of the primary targets for cerebral gene therapy. However, the cells, well-known for their poor function of endocytosis, are difficult to be transfected by general non-viral vectors," scientists writing in the Journal of Biomedical Science report.

"The aim of this study was to enhance the efficiency of transfection and expression in BCECs of DNA/polymer nanoparticles with the modification of membrane-penetrating peptide, Antennapedia peptide (Antp) polyethylenimine (PEI) and polyamidoamine (PAMAM) were chosen to prepare Antp-modified DNA-loaded nanoparticles with a complex coacervation...

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Source: Gene Therapy Weekly (2007-12-27)

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