Published in Gene Therapy Weekly, January 3rd, 2008
"ACE insertion ( I)/deletion ( D) polymorphism was studied in 141 CRC patients and 189 controls. ACE mRNA was upregulated in CRCs compared to corresponding nonlesional tissues ( 2.5-fold; P =.009). ACE protein was more commonly expressed in adenomas [ 17 ( 81%)] and cancer epithelial cells [ 22 ( 100%)] than in corresponding non-neoplastic crypt and...
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