Colon Cancer

Research conducted at Charite University has provided new information about colon cancer

Published in Gene Therapy Weekly, January 3rd, 2008

According to recent research from Berlin, Germany, "We studied the putative significance of angiotensin I-converting enzyme ( ACE) in colorectal cancer ( CRC) biology. Local expression of ACE was investigated by quantitative reverse transcription - polymerase chain reaction and by immunohistochemistry in CRCs and adenomas."

"ACE insertion ( I)/deletion ( D) polymorphism was studied in 141 CRC patients and 189 controls. ACE mRNA was upregulated in CRCs compared to corresponding nonlesional tissues ( 2.5-fold; P =.009). ACE protein was more commonly expressed in adenomas [ 17 ( 81%)] and cancer epithelial cells [ 22 ( 100%)] than in corresponding non-neoplastic crypt and...

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Source: Gene Therapy Weekly (2008-01-03)

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