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Heart Failure

Reports summarize heart failure research from University of Wurzburg

Published in Gene Therapy Weekly, January 10th, 2008

According to recent research published in the journal Circulation, "Cardiomyocyte hypertrophy is of central importance in the development of congestive heart failure. Whether proteins secreted from the myocardium itself contribute to myocardial hypertrophy is largely unknown."

"We performed a genetic yeast secretion trap screen using a murine cardiac cDNA library and identified 54 cardiac proteins that contained a secretion signal. When determining their mRNA expression in the myocardium of failing hearts, we found protease inhibitor 16 (PI16) to be strongly upregulated in hypertrophic and failing myocardium. PI16, a 489-amino acid protein with an unknown...

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