Published in Gene Therapy Weekly, January 17th, 2008
"Conditional replicating adenoviruses (CRAds) have proved particularly effective in initial preclinical and clinical studies. Requirements for construction of an effective CRAd are sufficient target cell specificity combined with efficient viral infection and replication. For this reason, we cloned triple-targeted oncolytic viruses with the following modifications: transcriptional targeting is...
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Source: Gene Therapy Weekly (2008-01-17)
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