Central Nervous System Disorders
Data on central nervous system disorders published by researchers at National Institute of Neurological Disorders and Stroke
Published in Gene Therapy Weekly, January 17th, 2008
According to recent research from the United States, "The mRNA encoding the Drosophila Zn-finger transcription factor Nerfin-1, required for CNS axon pathfinding events, is Subject to post-transcriptional silencing. Although neifin-1 mRNA is expressed in many neural precursor cells including all early delaminating CNS neuroblasts, the encoded Nerfin-1 protein is detected only in the nuclei of neural precursors that divide just once to generate neurons and then only transiently in nascent neurons."
"Using a nerfin-1 promoter-controlled reporter transgene, replacement of the nerfin-1 3' UTR with the viral SV-40 3' UTR releases the neuroblast translational block and...
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Source: Gene Therapy Weekly (2008-01-17)
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