Colon Cancer

Findings from INSERM advance knowledge in colon cancer

Published in Gene Therapy Weekly, January 17th, 2008

"Several genes have been recognized, when mutated in the germline, to highly predispose to colorectal cancer, impairing the DNA mismatch repair system in hereditary nonpolyposis colon cancer syndrome, or APC/MYH in adenomatous polyposis. However, 10 percent of microsatellite stable colorectal cancer is reported to develop in an unexplained context of genetic predisposition," investigators in Marseille, France report.

"This study was designed to depict the genetic mechanisms underlying early-onset microsatellite stable colon cancers. Patients younger than aged 50 years undergoing primary surgical resection for colon carcinoma were collected prospectively between 1993 and...

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Source: Gene Therapy Weekly (2008-01-17)

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