Gene Therapy

Data on gene therapy discussed by researchers at Charite University

Published in Gene Therapy Weekly, January 24th, 2008

"We determined the relation between promoter methylation and mRNA expression of the p53 target genes APAF-1 and DAPK-1 in 55 consecutive tumor and corresponding normal tissue samples. Tissue was taken from nonmetastatic clear cell renal cell carcinoma at a median followup of 75 months," investigators in Berlin, Germany report.

"Quantitative methylation specific real-time polymerase chain reaction and quantitative real-time reverse transcriptase-polymerase chain reaction were used. The mRNA expression levels of APAF-1 and DAPK-1 were significantly higher in tumor vs nontumor tissue from the same kidney (p = 0.003 and 0.0001, respectively). Expression levels of the 2...

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Source: Gene Therapy Weekly (2008-01-24)

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