Gene Therapy

Researchers at University of Texas, Health Science Center target gene therapy

Published in Gene Therapy Weekly, January 31st, 2008

Investigators publish new data in the report 'IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP- , NF-kappaB, and AP-1 activation.' According to a study from the United States, "Matrix metalloproteinases (MMPs) degrade collagen and mediate tissue remodeling. The novel cytokine IL-17 is expressed during various inflammatory conditions and modulates MMP expression."

"We investigated the effect of IL-17 on MMP-1 expression in primary human cardiac fibroblasts (HCF) and delineated the signaling pathways involved. HCF were treated with recombinant human IL-17. MMP-1 expression was analyzed by Northern blotting,...

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Source: Gene Therapy Weekly (2008-01-31)

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