Life Sciences
Investigators at University of Parma release new data on life sciences
Published in Gene Therapy Weekly, January 31st, 2008
New investigation results, 'The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes,' are detailed in a study published in Journal of Biological Chemistry. According to a study from Parma, Italy, "RNA-cleaving deoxyribozymes can be used for the sequence-specific knockdown of mRNAs. It was previously shown that activity of these deoxyribozymes is enhanced when their substrate-binding arms include some locked nucleic acid (LNA) residues, but the mechanistic basis of this enhancement was not explored."
"Here we dissected the kinetics and thermodynamics underlying the reaction of...
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Source: Gene Therapy Weekly (2008-01-31)
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