Enzyme Research
Reports by E. Sarnowska and co-researchers describe recent advances in enzyme research
Published in Gene Therapy Weekly, January 31st, 2008
"Aberrant expression of DNA polymerase beta, a key enzyme involved in base excision repair, leads to genetic instability and carcinogenesis. Pol beta expression has been previously shown to be regulated at the level of transcription, but there is also evidence of post-transcriptional regulation, since rat transcripts undergo alternative polyadenylation, and the resulting 30UTR contain at least one regulatory element," scientists in Warsaw, Poland report.
"Data presented here indicate that RNA of the short 30UTR folds to form a strong secondary structure (hairpin). Its regulatory role was established utilizing a luciferase-based reporter system. Further studies led to...
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Source: Gene Therapy Weekly (2008-01-31)
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