Gene Therapy
New gene therapy research from R. Zaccarini et al outlined
Published in Gene Therapy Weekly, January 31st, 2008
Scientists discuss in 'Pax6p46 binds chromosomes in the pericentromeric region and induces a mitosis defect when overexpressed' new findings in gene therapy. "Haploinsufficiency and overexpression of the Pax6 gene are responsible for defective central nervous system development. The purpose of the current work was to identify and characterize a new potential role for the Pax6 transcription factor in cellular proliferation in addition to its role at the level of gene expression," researchers in Orsay, France report.
"Expression vectors encoding tagged Pax6p46 protein were used to observe directly protein localization during the cell cycle in cells lines. Three...
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Source: Gene Therapy Weekly (2008-01-31)
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