Life Sciences
Researchers from University of Copenhagen, Institute of International Health detail new studies and findings in the area of life sciences
Published in Gene Therapy Weekly, February 7th, 2008
New investigation results, 'Molecular regulation of MHC class I chain-related protein A expression after HDAC-inhibitor treatment of Jurkat T cells,' are detailed in a study published in The Journal of Immunology. "In this study, we characterize the molecular signal pathways that lead to MHC class I chain-related protein A (MICA) expression after histone deacetylase (HDAC)-inhibitor (HDAC-i) treatment of Jurkat T cells. Chelating calcium with BAPTA-AM or EGTA potently inhibited HDAC-and CMV-mediated MICA/B expression," scientists in Copenhagen, Denmark report.
"It was further observed that endoplasmic reticulum calcium stores were depleted after HDAC treatment....
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Source: Gene Therapy Weekly (2008-02-07)
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