Glioblastoma

Findings in glioblastoma reported from Northwestern University

Published in Gene Therapy Weekly, February 7th, 2008

According to a study from the United States, "Altered glycosylation has been linked to cancer cell metastasis and invasivity. We have previously shown that expressing a specific sialyltransferase gene in gliomas inhibited tumor formation, in vivo."

"In order to identify other ''glyco-gene'' targets with therapeutic potential, focused 45-mer oligonucleotide microarrays were constructed containing all of the cloned human glyco-genes. Gene expression profiles of normal human brain and malignant gliomas were compared and microarray datasets analyzed using significance analysis of microarrays algorithms. There were 11 genes more highly expressed in gliomas compared to normal...

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Source: Gene Therapy Weekly (2008-02-07)

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