Synthetic Peptides

Findings from Firat University provide new insights into synthetic peptides

Published in Gene Therapy Weekly, February 7th, 2008

A new study, 'Analysis of direct and cross-presentation of antigens in TPPII knockout mice,' is now available. According to a study from Freiburg, Germany, "Tripeptidyl peptidase II (TPPII) is an oligopeptidase forming giant complexes in the cytosol that have high exo-, but also, endoproteolytic activity. Immunohistochemically, the complexes appear as distinct foci in the cytosol."

"In part controversial biochemical and functional studies have suggested that TPPII contributes, on the one hand, positively to Ag processing by generating epitope carboxyl termini or by trimming epitope precursors, and, on the other, negatively by destroying potentially antigenic peptides....

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Source: Gene Therapy Weekly (2008-02-07)

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