Gene Therapy

Findings in gene therapy reported from University College

Published in Gene Therapy Weekly, February 7th, 2008

According to a study from London, the United Kingdom, "Sirolimus is a potent immunosuppressive agent, which is associated with dyslipidemia in clinical transplantation. The present study was undertaken to investigate the potential hepatocyte mechanisms by which sirolimus causes dyslipidemia."

"Using both a quantitative assay of intracellular cholesterol and an [H-3] -labeled cholesterol efflux assay, we studied the effect of sirolimus on cholesterol accumulation and cholesterol efflux in HepG2 cells in the absence or presence of inflammatory stress induced by interleukin-1 beta. The gene and protein expression of molecules involved in cholesterol homeostasis were...

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Source: Gene Therapy Weekly (2008-02-07)

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