Gene Therapy
New gene therapy data have been reported by researchers at University of Virginia
Published in Gene Therapy Weekly, February 7th, 2008
According to recent research published in the journal Circulation Research, "There has been considerable controversy regarding the lineage relationship between smooth muscle cells (SMCs) and myofibroblasts, because they express a number of common cell-selective markers including smooth muscle (SM) alpha-actin. We have shown previously that MCAT elements within the SM alpha-actin promoter confer differential activity in cultured SMCs versus myofibroblasts."
"In the present study, to determine the role of MCAT elements in vivo, we generated transgenic mice harboring an SM alpha-actin promoter-enhancer-LacZ reporter gene containing MCAT element mutations and...
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Source: Gene Therapy Weekly (2008-02-07)
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