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Renal Cell Carcinoma

Researchers from Shanghai Jiao Tong University, Medical Department provide details of new studies and findings in the area of renal cell carcinoma

Published in Gene Therapy Weekly, February 7th, 2008

"Von Hippel-Lindau (VHL) disease is a rare autosomal dominant disorder caused by germ line mutations of the VHL tumour suppressor gene," investigators in Shanghai, People's Republic of China report.

"It predisposes affected individuals to develop a variety of neoplasms, including haemangioblastomas of the central nervous system, retinal angiomas, renal cell carcinomas (RCCs), pheochromocytomas and cysts of the kidneys and epididymis. Germ line VHL mutations have been found in all VHL disease families.(1) RCC occurs in 25% to 45% of patients with VHL disease and is one of the leading causes of death.(2) As the RCCs in VHL disease tend to be multifocal and bilateral, the...

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