Renal Cell Carcinoma

Study findings on renal cell carcinoma are outlined in reports from University of Munich

Published in Gene Therapy Weekly, February 7th, 2008

According to a study from Munich, Germany, "The inflammatory enzyme indoleamine 2,3-dioxygenase (IDO) participates in immune tolerance and tumor immune escape processes by degradation of the essential amino acid tryptophan and formation of toxic catabolites. Here, we analyzed the role of IDO in tumor growth and disease progression in patients with clear cell renal cell carcinoma (RCC)."

"Expression of IDO mRNA was analyzed by quantitative reverse transcription-PCR in 55 primary and 52 metastatic RCC, along with 32 normal kidneys. Western blot and immunohistochemistry analyses were used to semiquantitatively determine IDO proteins in a subset of tumor samples, in RCC...

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Source: Gene Therapy Weekly (2008-02-07)

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