Angiogenesis

New angiogenesis research from University of Heidelberg described

Published in Gene Therapy Weekly, February 7th, 2008

"Purpose Human troponin I (TROP), the soluble receptor for vascular endothelial growth factor (sFLT) and angiostatin (ASTAT) are potent inhibitors of endothelial cell proliferation, angiogenesis and tumour growth in vivo. Transfer of these genes into tumours may induce changes not only in perfusion, but also more general ones such as changes in metabolism," investigators in Heidelberg, Germany report.

"The aim of this study was to assess these reactions using FDG-PET and high-throughput methods such as gene profiling. Methods We established Morris hepatoma (MH3924A) cell lines expressing TROP, sFLT or ASTAT and quantified F-18-fluorodeoxyglucose ((18)FDG) uptake by...

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Source: Gene Therapy Weekly (2008-02-07)

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