Fibrosis Genetics
Recent findings from Ohio State University highlight research in fibrosis genetics
Published in Gene Therapy Weekly, February 7th, 2008
Current study results from the report, 'Cystic fibrosis transmembrane conductance regulator trafficking is mediated by the COPI coat in epithelial cells,' have been published. "Cystic fibrosis (CF) is caused by defects in the CF transmembrane conductance regulator (CFTR) that functions as a chloride channel in epithelial cells. The most common cause of CF is the abnormal trafficking of CFTR mutants," investigators in the United States report.
"Therefore, understanding the cellular machineries that transit CFTR from the endoplasmic reticulum to the plasma membrane (PM) is important. The coat protein complex I (COPI) has been implicated in the anterograde and retrograde...
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Source: Gene Therapy Weekly (2008-02-07)
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