Life Sciences

Duke University, Department of Biomedical Engineering details research in life sciences

Published in Gene Therapy Weekly, February 14th, 2008

Current study results from the report, 'Mechanistic analysis of electroporation-induced cellular uptake of macromolecules,' have been published. "Pulsed electric field has been widely used as a nonviral gene delivery platform. The delivery efficiency can be improved through quantitative analysis of pore dynamics and intracellular transport of plasmid DNA," scientists in the United States report.

"To this end, we investigated mechanisms of cellular uptake of macromolecules during electroporation. In the study, fluorescein isothiocyanate-labeled dextran (FD) with molecular weight of 4,000 (FD-4) or 2,000,000 (FD-2000) was added into suspensions of a murine mammary...

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Source: Gene Therapy Weekly (2008-02-14)

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