Gene Therapy
Research from University of Rochester has provided new data on gene therapy
Published in Gene Therapy Weekly, February 14th, 2008
"Sphingosine-1-phosphate (S-1-P) is a bioactive sphingolipid that stimulates the migration of vascular smooth muscle cell (VSMC) through G-protein coupled receptors; it has been shown to activate reduced nicotinamide dinucleotide phosphate hydrogen (NAD[P]H) oxidase. The role of phospholipase C (PLC) in oxygen free radical generation, and the regulation of VSMC migration in response to S-1-P, are poorly understood," scientists writing in the Journal of Vascular Surgery report.
"Rat arterial VSMC were cultured in vitro. Oxygen free radical generation was measured by fluorescent redox indicator assays in response to S-1-P (0.1 mc M) in the presence and absence of...
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Source: Gene Therapy Weekly (2008-02-14)
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