New angiogenesis study findings have been reported by researchers at Wayne State University

"Platelet-derived growth factor-D (PDGF-D) signaling plays critical roles in the pathogenesis and progression of human malignancies; however, the precise mechanism by which PDGF-D causes tumor cell invasion and angiogenesis remain unclear. Because Notch-1, nuclear factor-kappa B (NF-kappa B), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMP) are critically involved in the processes of tumor cell invasion and metastasis, we investigated whether PDGF-D down-regulation could be mechanistically associated with the down-regulation of Notch-1, NF-kappa B, VEGF, and MMP-9, resulting in the inhibition of tumor cell invasion and angiogenesis," investigators in the...

Want to see the full article?

• Purchase this article for only $3.00