Gene Therapy
Studies from University of Rochester provide new data on gene therapy
Published in Gene Therapy Weekly, February 28th, 2008
Research findings, 'Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors,' are discussed in a new report. "The high affinity Fcgamma receptor I (FcgammaRI; aka CD64) is expressed by dendritic cells (DC) and antigens targeted to this receptor elicit enhanced immune responses. This study was designed to test the hypothesis that targeting an adenoviral (Ad) vector to FcgammaRI would lead to enhanced transduction of DC and an improved immune response to vector-encoded antigens," scientists in the United States report.
"A bispecific adaptor molecule consisting of a trimeric adenovirus fiber-binding moiety fused to a single-chain antibody specific...
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Source: Gene Therapy Weekly (2008-02-28)
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