Bioengineering

Report summarizes bioengineering study findings from Northwestern University, Medical Department

Published in Gene Therapy Weekly, March 6th, 2008

"Peroxisome proliferators activate nuclear receptor peroxisome proliferator-activated receptor alpha ( PPAR alpha) and enhance the transcription of several genes in liver. We report here that synthetic PPAR alpha ligands Wy-14,643, ciprofibrate, clofibrate, and others induce the nuclear translocation of constitutive androstane receptor (CAR) in mouse liver cells in vivo," scientists in the United States report.

"Adeno-viral-enhanced green fluorescent protein-CAR expression demonstrated that PPAR alpha synthetic ligands drive CAR into the hepatocyte nucleus in a PPAR alpha- and PPAR beta-independent manner. This translocation is dependent on the transcription coactivator...

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Source: Gene Therapy Weekly (2008-03-06)

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