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Pancreatic Cancer

Research conducted at Technical University of Munich has provided new information about pancreatic cancer

Published in Gene Therapy Weekly, March 13th, 2008

"Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential target for chemoprevention," scientists writing in the journal Neoplasia report.

"Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenase (5-LOX) has been suggested as a tumor promoter in pancreatic carcinogenesis. Here we provide evidence that 15-lipoxygenase- 1 (15-LOX-1) expression and activity may exert antitumorigenic effects in pancreatic cancer. Reverse transcription - polymerase chain reaction ( RTPCR) and Western blot analysis showed...

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