Antivirals

Research from Pohang University of Science and Technology reveals new findings on antivirals

Published in Gene Therapy Weekly, March 20th, 2008

"Bach2, a bZIP transcription factor originally identified as interacting with the small Maf family of bZIP proteins, has been shown to play important roles in oxidative stress-mediated cell death. Here, we examine the role of Bach2 in cell death during double-stranded (ds)RNA- and dsDNA-triggered antiviral innate immune responses," investigators in South Korea report.

"Bach2 expression was induced in HeLa cells upon dsRNA/dsDNA treatment and the suppression of Bach2 expression by siRNA treatment alleviated cell death triggered by dsRNA and dsDNA. Unexpectedly, DNA microarray analysis revealed that siRNA-mediated suppression of Bach2 resulted in the attenuated activation...

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Source: Gene Therapy Weekly (2008-03-20)

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