Asthma

Study findings from National Taiwan University provide new insights into asthma

Published in Gene Therapy Weekly, March 27th, 2008

"GATA-3 is the key transcriptional factor for Th2 commitment in T cells and is strongly associated with asthma and allergic disease. We studied the silencing of the GATA-3 gene expression using RNA interference (RNAi) delivered by a lentiviral vector, to evaluate the therapeutic role of GATA-3 short hairpin RNAs (shRNAs) in a murine model of asthma," scientists in Taipei, Taiwan report.

"Mice were sensitized with OVA and instilled intratracheally (IT) with GATA-3 shRNAs lentiviral vector (LentisiGATA-3) once, 48 hours before challenge. After three challenges with the OVA antigen, the mice were assessed for airway hyperresponsiveness (AHR) and inflammation. With...

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Source: Gene Therapy Weekly (2008-03-27)

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