RNA Research

Researchers at McGill University target RNA research

Published in Gene Therapy Weekly, April 3rd, 2008

"The integrin family of heterodimeric transmembrane receptors mediates cell-matrix adhesion. Integrins often localize in highly organized structures, such as focal adhesions in tissue culture and myotendinous junctions in muscles," scientists writing in the Journal of Cell Biology report.

"Our RNA interference screen for genes that prevent integrin-dependent cell spreading identifies Z band alternatively spliced PDZ-motif protein ( zasp), encoding the only known Drosophila melanogaster Alp/Enigma PDZ-LIM domain protein. Zasp localizes to integrin adhesion sites and its depletion disrupts integrin adhesion sites. In tissues, Zasp colocalizes with beta PS integrin...

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Source: Gene Therapy Weekly (2008-04-03)

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