Gene Therapy
Reports on gene therapy findings from L. Li and co-researchers provide new insights
Published in Gene Therapy Weekly, April 3rd, 2008
According to recent research from Shanghai, People's Republic of China, "Saframycin A (SFM-A), produced by Streptomyces lavendulae NRRL 11002, belongs to the tetrahydroisoquinoline family of antibiotics, and its core is structurally similar to the core of ecteinascidin 743, which is a highly potent antitumor drug isolated from a marine tunicate. In this study, the biosynthetic gene cluster for SFM-A was cloned and localized to a 62-kb contiguous DNA region."
"Sequence analysis revealed 30 genes that constitute the SFM-A gene cluster, encoding an unusual nonribosomal peptide synthetase (NRPS) system and tailoring enzymes and regulatory and resistance proteins. The...
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Source: Gene Therapy Weekly (2008-04-03)
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