Enzyme Research

Reports from Juntendo University, Medical Department describe recent advances in enzyme research

Published in Gene Therapy Weekly, April 10th, 2008

According to a study from Hongo, Japan, "Nuclear factor-kappa B (NF-kappa B) inhibits cell death through suppression of the caspase cascade, the c-Jun N-terminal kinase (JNK) pathway, and reactive oxygen species (ROS) accumulation. To suppress this antiapoptotic function of NF-kappa B might be a promising strategy to increase susceptibility of tumor cells to stress-induced cell death."

"We have recently shown that tumor necrosis factor (TNF)alpha induces caspase-dependent and -independent JNK activation and ROS accumulation in cellular FLICE-inhibitory protein (c-Flip)(-/-) murine embryonic fibroblasts (MEFs). To apply this observation to tumor therapy, we knocked down...

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Source: Gene Therapy Weekly (2008-04-10)

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