Gene Therapy

Recent findings from University of Chile highlight research in gene therapy

Published in Gene Therapy Weekly, April 10th, 2008

According to recent research from Santiago, Chile, "The synaptic membrane-associated guanylate kinase ( MAGUK) scaffolding protein family is thought to play key roles in synapse assembly and synaptic plasticity. Evidence supporting these roles in vivo is scarce, as a consequence of gene redundancy in mammals."

"The genome of Drosophila contains only one MAGUK gene, discs large (dlg), from which two major proteins originate: DLGA [PSD95(postsynaptic density 95)-like] and DLGS97 [SAP97 (synapse-associated protein)-like]. These differ only by the inclusion in DLGS97 of an L27 domain, important for the formation of supramolecular assemblies. Known dlg mutations affect both...

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Source: Gene Therapy Weekly (2008-04-10)

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