Leukemia
Research by Q.F. Li and colleagues in leukemia provides new insights
Published in Gene Therapy Weekly, April 10th, 2008
According to recent research from Beijing, People's Republic of China, "The signaling mechanisms responsible for BCR/ABL-induced regulation of Mcl-1 expression in chronic myelogenous leukemia (CML) cells remain unclear. In this study, we show that BCR/ABL could upregulate sphingosine kinase-1 (SPK1) expression via multiple signal pathways, including mitogen-activated protein kinase ( MAPK), phosphoinositide 3-kinase (PI3K) and Janus kinase 2 (JAK2), leading to increase cellular SPK1 activity in CML cells."
"Retrovirus-mediated overexpression of bcr-abl gene in NIH-3T3, Ba/F3 and HL-60 cells results in upregulation and increased cellular activity of SPK1, whereas...
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Source: Gene Therapy Weekly (2008-04-10)
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