Bladder Cancer

Study results from Medical University of South Carolina update understanding of bladder cancer

Published in Gene Therapy Weekly, April 10th, 2008

"Recently, we reported prognostic significance of thromboxane synthase (TXAS) gene expression in invasive bladder cancer. The positive correlation between elevated TXAS expression and shorter patient survival supports a potential role for TXAS-regulated pathways in tumor metastases," scientists in the United States report.

"In this study, using immunohistochemical analysis, we found an increased expression of TXAS protein in bladder cancer. Treatment of T24 and transitional cell carcinoma TCC-SUP bladder cancer cells with the TXAS inhibitors furegrelate or ozagrel induced an apoptotic effect measured as an increase in caspase-3 activation and cell death, and decreased...

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Source: Gene Therapy Weekly (2008-04-10)

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