Gastric Cancer Genetics

Research on gastric cancer genetics discussed by scientists at Ohio State University

Published in Gene Therapy Weekly, April 10th, 2008

A report, 'E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer,' is newly published data in Cancer Cell. According to recent research published in the journal Cancer Cell, "Deregulation of E2F1 activity and resistance to TGFbeta are hallmarks of gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs frequently misregulated in human malignancies."

"Here we provide evidence that the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA-directed negative...

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Source: Gene Therapy Weekly (2008-04-10)

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