Gene Therapy
Researchers at Chang-Gung University, Department of Anesthesiology publish new data on gene therapy
Published in Gene Therapy Weekly, April 17th, 2008
New research, 'Intrathecal coelectrotransfer of a tetracycline-inducible, three-plasmid-based system to achieve tightly regulated antinociceptive gene therapy for mononeuropathic rats,' is the subject of a report. According to recent research from Taiwan, "For optimal use of antinociceptive gene therapy, it may be important to have extrinsic control of the expression of the transfected gene. To achieve this goal, we used a tetracycline-inducible system (Tet-On) composed of three plasmids coding for beta-endorphin, the tetracycline transcriptional activator rtTA, and the silencer tTS."
"The regulation of beta-endorphin expression was first assessed in cultures of dorsal...
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Source: Gene Therapy Weekly (2008-04-17)
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