Gene Therapy
New gene therapy study findings have been published by Y.H. Chen and colleagues
Published in Gene Therapy Weekly, April 17th, 2008
According to a study from Taipei, Taiwan, "This study determined the consequences of dopamine denervation of the striatum on synaptic plasticity and prevention of these changes with gene therapy using an adeno-associated viral vector (AAV) expressing glial cell line-derived neurotrophic factor (GDNF). C57BL6/J mice were injected with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); long-term depression (LTD) or potentiation (LTP) were measured in vitro."
"Fast-scan cyclic voltammetry measured electrically released dopamine from a functionally relevant pool in these same striatal slices. After MPTP, dopamine release and uptake were greatly diminished,...
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Source: Gene Therapy Weekly (2008-04-17)
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