Researchers from University of Paris describe findings in gene therapy

New investigation results, 'ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver,' are detailed in a study published in The Journal of Clinical Investigation. "The transcription factor carbohydrate-responsive element-binding protein (ChREBP) has emerged as a central regulator of lipid synthesis in liver because it is required for glucose-induced expression of the glycolytic enzyme liver-pyruvate kinase (L-PK) and acts in synergy with SREBP to induce lipogenic genes such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). Liver X receptors (LXRs) are also important regulators of the lipogenic pathway, and the recent finding that...

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