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Measles

Report summarizes measles study findings from Philipps University, Institute of Virology

Published in Gene Therapy Weekly, April 24th, 2008

Researchers detail in 'Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes,' new data in measles. "We previously demonstrated the presence of tyrosine-dependent motifs for specific sorting of two measles virus (MV) glycoproteins, H and F, to the basolateral surface in polarized epithelial cells. Targeted expression of the glycoproteins was found to be required for virus spread in epithelia via cell-to-cell fusion in vitro and in vivo," scientists writing in the Journal of General Virology report.

"In the present study, recombinant MVs (rMVs) with substitutions of the critical tyrosines in...

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