DNA Research

Data on DNA research detailed by investigators at National Human Genome Research Institute

Published in Gene Therapy Weekly, April 24th, 2008

According to recent research from the United States, "Knowledge of all binding sites for transcriptional activators and repressors is essential for computationally aided identification of transcriptional networks. The techniques developed for defining the binding sites of transcription factors tend to be cumbersome and not adaptable to high throughput."

"We refined a versatile yeast strategy to rapidly and efficiently identify genomic targets of DNA-binding proteins. Yeast expressing a transcription factor is mated to yeast containing a library of genomic fragments cloned upstream of the reporter gene URA3. DNA fragments with target-binding sites are identified by...

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Source: Gene Therapy Weekly (2008-04-24)

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