DNA Research

Researchers from University of Tokyo provide details of new studies and findings in the area of DNA research

Published in Gene Therapy Weekly, April 24th, 2008

"Regulation of chromatin in eukaryotic transcription requires histone-modifying enzymes, nucleosome remodeling complexes, and histone chaperones. Specific regulation of histone incorporation/eviction by histone chaperones on the promoter (e.g., region specific) is still poorly understood," scientists in Hongo, Japan report.

"In the present study, we show that direct and functional interaction of histone chaperone and DNA-binding transcription factor leads to promoter region-specific histone incorporation and inhibition of histone acetylation. We report here that the DNA-binding transcription factor Kruppel-like factor 5 (KLF5) interacts with the novel histone chaperone...

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Source: Gene Therapy Weekly (2008-04-24)

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